Ultrasensitive chemical and biological analysis via. Optofluidic realization and retaining of cellcell contact. Dual characterization of biological cells by optofluidic. The geometries that have been incorporated into the microfluidic channels for promoting mixing efficiency.
Developing optofluidic technology through the fusion of microfluidics and optics. Optofluidic microsystems for chemical and biological. The primary chemical parameters of ocean monitoring include nutrients, ph, dissolved oxygen do, and heavy metals. Lim, an optofluidic approach for characterization of phytoplankton, bmes annual meeting, atlanta, ga, october 2427 2012 pdf 11. Porous thin films, optofluidics, microfluidics, photonic crystals. Integrated optofluidics holds abundant promise for biological and chemical research by miniaturizing complex optical and fluidic functionalities to the micronanoscale 18. Manipulation of microscale fluid using laserirradiated. The volume reduction of radioactive solutions is especially attractive in order to reduce the workers radiation exposition in the context of offline analysis in spent nuclear fuel reprocessing plants. Optofluidic resonators are optical microcavities that are partially or completely made of liquids. Our lab has been working on diverse optofluidic devices for biologicalchemical analysis. The qualityfactor of the fpc channel is 875, and the system noise can.
Optofluidic photonic crystal microsystems for chemicalbiomedical applications there is an increasing research trend for the fabrication of a novel generation of dropandmeasure optofluidic microsystems ofms for label free biologicalchemical analysis that integrate materials with unique optical properties in microfluidic systems, among. An all glass optofludic biosensor with high qualityfactor fabryperot cavity fpc channel was reported. A wide solidcore optical waveguide acts as an mmi waveguide in which numerous waveguide modes with different propagation constants interfere as they propagate along the structure. Pdf optofluidic microsystems with integrated vertical. Development of an optofluidic microsystem dedicated to chemical. The all glass sandwich structure can completely eliminate the etching roughness of the channel surface, and can extend the operating wavelength to visible and ultraviolet regions compared with that of sibased sensor.
Optofluidic maskless lithography system for realtime synthesis of photopolymerized microstructures in microfluidic channels. In 12 chapters distinguished scientists and leaders in their respective fields show how various optical technologies have been miniaturized and integrated over the last few decades in order to be combined with nano and microsystems for applications in the life sciences. Micromachines free fulltext autonomous and in situ. Mixing is one of the dominating processes in chemical reactions and analyses. Developing optofluidic technology through the fusion of microfluidics. Potentially fetched functionalities in labonachip or microsystems through optofluidic technology have provided better mitigation in medical diagnostics 1, 2, biooptical computing 3, water treatments 4, 5, electronic switches 6, imaging devices 3, 6, photovoltaic cells 7, 8, biochemical sensors, and integrated sensorsactuators 9, 10. Examples of biological gain media include vitamin in droplets 3 and a distributed feedback cavity 4 and green fluorescent proteins 5, 6 gfps in a fabryperot 7, 8 or ring resonators 9, 10. Biology, biomedical engineering society bmes and chemical and biological microsystems society cbms, ieee education society present 2011science fair judge, science and engineering fair of metro detroit sefmd, wayne state junior sciences symposium, and first robotics southeast michigan. Integrated microchips for biological analysis fabricated. Optofluidic microsystems for chemical and biological analysis article in nature photonics 510. Flow effects in the laserinduced thermal loading of. Ultrasensitive chemical and biological analysis via specialty fibers with builtin microstructured optofluidic channels nan zhang, ab kaiwei li, a ying cui, ab zhifang wu, ab perry ping shum, ab jeanlouis auguste, c xuan quyen dinh, bd georges humbert c and lei wei ab.
Hammond, 2,3 and henry du1 1department of chemical engineering and materials science, stevens institute of technology, hoboken, nj 07030, usa. Optofluidics is a rising technology that combines microfluidics and optics. Microspheres, photonic atoms and the physics of nothing light can become trapped within tiny, transparent spheres. Optofluidic liquid sensing on electromicrofluidic devices iopscience. Biological function is contextdependent, and in vitro study of a biological system is often limited to a predefined chemical environment chosen to recapitulate facets of the systems function in. An ultralow detectionlimit optofluidic biosensor based. Dielectrophoresisactuated inplane optofluidic lens with tunability of focal length from negative to positive. Osa optofluidic refractiveindex sensors employing bent. Furthermore, optofluidic microsystems can also employ optical forces in tandem with microfluidics to trap and manipulate targets 7, thus further enhancing the system s analytical capabilities. Optofluidic tweezers featured in nsf year of light. Phcs have attracted great attention in the field of biologicalchemical analysis for.
Journal of the european optical society rapid publications, vol 10 2015. Bansai an optofluidic approach for biomedical analysis. This emerging technology enables high throughput study and analysis of chemical and biological molecules through their detection and manipulation onchip. Optofluidic lasers are currently of high interest for sensitive, intracavity, biochemical analysis. Optofluidic microsystems for chemical and biological analysis pp 591 597. Optical nano and microsystems for bioanalytics springerlink. Fan x, white im 2011 optofluidic microsystems for chemical and biological analysis. Optofluidic microsystem with quasi3 dimensional gold. Rapid characterization of biomolecules thermal stability.
Flow effects in the laserinduced thermal loading of optical traps and optofluidic devices. Optofluidics the synergistic integration of photonics and microfluidics is a new analytical field that provides a number of unique characteristics for enhancing the sensing performance and simplifying the design of microsystems. Optofluidic microsystems for chemical and biological analysis. Optofluidic microsystems with integrated vertical onedimensional. Optofluidic laser array based on stable high q fabry. Optofluidic sersthe synergistic use of microfluidics to improve the performance of sersmay finally lead to practical devices for chemical and biomolecular detection. Gold nanoparticle incorporated inverse opal photonic. Microchips have revolutionized biological analysis since they can be used to perform biochemical analysis with high efficiency and accuracy.
In this paper, we demonstrate a dual analysis of biological cells using a single microfluidic system combining optofluidic microscopy and resistive pulse sensing. Optofluidic tunable lenses for inplane light manipulation mdpi. Sensors based on optofluidic resonators use either passive cavity resonance shift or active lasing to detect small changes in refractive index, absorption, gain, or scattering in the vicinity of the resonator. Optofluidics is an emerging research field that combines optics and photonics with microfluidics in the same platform and exploits the synergy between the unique features of both disciplines for a wide range of applications including biological sensing 1,2, chemical analysis, imaging 35, detection 2,68 and energy conversion 914. The chemical and biological microsystems society cbms is a non profit organization without membership, aiming at the promotion and advancement of science and engineering in the field of chemical and biological microsystems, and to stimulate the exchange of ideas and information between academic, industrial, and government researchers. The photonic integration of nonsolid media using optofluidics. The crosssection of fiber can be used as a microcavity, providing optical feedback. Recent advances in optofluidics offer tremendous opportunities for biologicalchemical analysis using extremely small sample volumes. Giri babu sinnapolu successfully defended his ms thesis, and has accepted a position as a research engineer at ford research and. This article overviews the stateoftheart of optofluidic architectures in biochemical analysis. Its goal is to manipulate light and flowing liquids on the micronanoscale and exploiting their interaction in optofluidic chips. Femtosecond laser direct writing followed by wet chemical etching can be used to fabricate hollow microstructures with almost any threedimensional 3d structure without stacking or bonding. Labonfiber optofluidic platform for in situ monitoring. Optofluidics the synergistic integration of photonics and microfluidics has recently emerged as a new analytical field that provides a number of unique.
Development of an optofluidic platform in lithium niobate. Optofluidic analysis system for amplificationfree, direct. Gold nanoparticle incorporated inverse opal photonic crystal capillaries for optofluidic surface enhanced raman spectroscopy. Optofluidic microsystems for chemical and biological analysis ncbi. The combination of optofluidic techniques with optofluidic sensing has led to inherently integrated methods for the analysis of biological micro and nanoparticles in microsystems.
Both red blood cells rbcs and circulating tumor cells ctcs have been used to validate the concept of dual analysis and also to test the performance of the microfluidic device. Performance and flow dynamics studies of polymeric. Labonfiber optofluidic platform for insitu monitoring of drug release from therapeutic eluting polyelectrolyte multilayers fei tian, 1, jouha min,2,3 jiri kanka,4 xiangzhi li,1 paula t. Basu received an nsf grant from cbet cbs division for the proposal fractionation, purification, and analysis of gases in microbubbles. At propagation distances where the relative phases of these modes. Dielectrophoresisactuated inplane optofluidic lens with.
Recent trends in developing nanodevices for detection and realtime monitoring of biomolecular events, sensors 16. In 12 chapters distinguished scientists and leaders in their respective fields. Singlevirus analysis through chipbased optical detection. Sersbased optofluidic microsystems using ag or au colloidal nanoparticles as sersactive substrates have been applied for rapid trace analysis of chemical analytes, such as insecticides, toxic chemicals, and environmental pollutants,, as well as for a variety of biological analytes. The fluid flow in the onchip devices is reconfigurable, nonuniform and usually transports substances being analyzed, offering a new idea in the accurate manipulation of lights and. Hashemi, optofluidic cytometry on a chip, asme summer bioengineering conference, fajardo, puerto rico, june 2023 2012 pdf. Piezophototronic gated optofluidic logic computations. School of chemistry and chemical engineering, fuzhou university.
Pdf a fast and reproducible elisa laser platform for. Optofluidic microsystems for chemical and biological analysis, nat. Thus further enhances the systems analytical capabilities 19. The microcavity enhances the lightmatter interaction, thus increasing the sensitivity. This book describes the state of the art in the field of bioanalytical nano and microsystems with optical functionality. Although the term optofluidics is less than 10 years old, the combination of light. Whiteoptofluidic microsystems for chemical and biological analysis. Additionally, optofluidic microsystems can employ optical forces in concert with microfluidics to trap and manipulate targets to enhance the analytical capabilities 17. Development of an optofluidic microsystem dedicated to chemical analysis in a. In this work, we report allsilicon, integrated optofluidic microsystems ofms. This article overviews the stateoftheart of optofluidic architectures in bio chemical analysis. Furthermore, optofluidic microsystems can also employ optical forces as noncontact means for trapping, manipulation, and separation in microsystems.
Highthroughput singlemolecule optofluidic analysis. With microfluidic technology, various schemes have been conceived and implemented to realize highly efficient mixing of liquids by manipulating micro and nanoscale fluids in sophisticated manners 1,2,3,4,5,6. In summary, for the etching of har complex microsystems for optofluidic. Optofluidic microsystems with integrated vertical onedimensional photonic crystals for chemical analysis article pdf available in lab on a chip 1221. Labonachip based portable blood analysis systems would allow pointofcare measurements, e. The chemical and biological microsystems society cbms. Optical nano and microsystems for bioanalytics wolfgang. Optofluidics, microfluidics and nanofluidics, volume 2, issue 1, pages 2230. Fiber optofluidic laser can detect the biochemical changes using its laser output as a sensing signal. Optofluidic microsystems for chemicaland biological analysis. White, optofluidic microsystems for chemical and biological analysis, nat. In comparison with conventional methods such as fluorescence and colorimetric detection. Development of an optofluidic microsystem dedicated to.
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